Over the weekend, Geraldine Fabrikant in the Times wrote an intriguing piece about Jane Mendillo, who had the misfortune of stepping into the job of head of the Harvard Management Company just before the stock market crashed.

Her critics say that Ms. Mendillo’s overall investment strategy is unclear and that while the crisis erupted faster and with more magnitude than could have been predicted, she could have moved more quickly to manage the risk. Supporters counter that her predecessors essentially left her hamstrung with a portfolio that was illiquid, and give her high marks on investing acumen.

The article implies that some of Harvard’s riskier investment stratagems, which looked so promising in happier times, are costing the university billions now.

And it suggests to me that Harvard is in a very delicate position at the moment: In a time of crisis, it has a new president and, perhaps even more important, a new investment management head—its third in, what, the last four years?—both of whom can only be described as untested. That status is, of course, rapidly changing.

Will Drew Faust and Jane Mendillo rise to the occasion?

Because make no mistake, this is a watershed moment in Harvard’s history, probably the most important one—even more than the events of 2005-2006—since 1968. How these two women fare will affect Harvard’s culture and growth for years to come.